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Development of small nerve fibre pathology in chronic whiplash-associated disorder

2021 RBWH and RBWH Foundation Research Project Grant
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Project description

This research focuses on understanding why some individuals develop long-term neck pain after a whiplash neck injury (for example, in a car crash), while others recover without issues. By studying the neurological, inflammatory and psychological factors involved, we aim to shed light on the underlying mechanisms of chronic pain following whiplash injuries.

Why this work is needed

Many people who experience whiplash injuries suffer from long-term neck pain, but current treatments often fall short in preventing chronicity. Additionally, the lack of clear biological explanations for ongoing symptoms can lead to stigma, particularly in cases involving compensation claims. Through the analyses of skin biopsies and blood samples to investigate potential small nerve fiber pathology and inflammatory markers, Dr Scitt Farrell's research seeks to address these gaps by identifying neurological factors contributing to long-term pain. This could lead to more effective clinical management and reduce societal stigma associated with whiplash injuries.

Outcomes

The preliminary results are from 19 patients with acute whiplash. Of them, approximately 43% have recovered, while another 43% experience ongoing mild to moderate neck pain-related disability. Around 14% continue to suffer from moderate to severe neck pain-related disability. By identifying subtle neurological pathology, observed through skin biopsies and blood samples, we may develop targeted treatment strategies, such as neuropathic pain medications, to alleviate symptoms and improve patient outcomes. Moreover, our findings could challenge existing stigmas by providing tangible biological explanations for ongoing pain, ultimately leading to more empathetic and effective clinical care for the 28% of individuals who experience chronic neck pain after whiplash injuries.

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Meet the Researcher

Dr Scott Farrell

Physiotherapist

View Researcher Bio